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Yunlu Dai, Xiaojiao Kang, Dongmei Yang, Xuejiao Li, Xiao Zhang, Chunxia Li, Zhiyao Hou, Ziyong Cheng, Ping'an Ma and Jun Lin Drug Delivery: Platinum (IV) Pro-Drug Conjugated NaYF4:Yb3+/Er3+ Nanoparticles for Targeted Drug Delivery and Up-Conversion Cell Imaging (Adv. Healthcare Mater. 4/2013) Advanced Healthcare Materials 2

Version of Record online: 5 APR 2013 | DOI: 10.1002/adhm.201370019

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A folic acid targeted anticancer drug delivery system based on Pt (IV) complexes pro-drug conjugated upconversion NaYF4:Yb3+/Er3+ nanoparticles is developed. As reported by Jun Lin, Ping'an Ma, and co-workers on page 562, the platinum (IV) complexes as pro-drugs can exhibit anti-cancer activities when the platinum (IV) complexes are reduced to platinum (II) in the intracellular environment. The nanoparticles show bright upconversion fluorescence under 980 nm laser excitation; thus, the as-prepared nanoparticles can be used as a luminescent probe for up-conversion cell imaging.

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