Vanessa L. S. LaPointe, Ana Tiago Fernandes, Nia C. Bell, Francesco Stellacci and Molly M. Stevens Stem Cells: Nanoscale Topography and Chemistry Affect Embryonic Stem Cell Self-Renewal and Early Differentiation (Adv. Healthcare Mater. 12/2013) Advanced Healthcare Materials 2
On page 1644, Molly M. Stevens and team show how embryonic stem cells can sense nanoscale topography and chemistry from surfaces composed of 4.5 nm gold monolayer-protected metal nanoparticles with varying shell composition. Early differentiation markers are influenced by both variables, suggesting a synergistic role for topographical features and surface chemistry in influencing stem cell behavior.
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