M.P. Lutolf, G.P. Raeber, A.H. Zisch, N. Tirelli and J.A. Hubbell Cell-Responsive Synthetic Hydrogels Advanced Materials 15
Synthetic biomaterial matrices have been formed in the presence of cells by a Michael-type addition reaction between a difunctional protease substrate peptide, a monofunctional cell adhesion peptide, and a tetrafunctional poly(ethylene glycol). These materials locally degrade in response to cell-surface proteases, allowing cells to create paths for 3D cell migration (see Figure).
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