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N. Jessel, F. Atalar, P. Lavalle, J. Mutterer, G. Decher, P. Schaaf, J.-C. Voegel and J. Ogier Bioactive Coatings Based on a Polyelectrolyte Multilayer Architecture Functionalized by Embedded Proteins Advanced Materials 15

Article first published online: 25 APR 2003 | DOI: 10.1002/adma.200304634

Does a signal protein imbedded in a polyelectrolyte layer keep its activity? The study reported here demonstrates that cells can indeed interact with proteins incorporated in poly(L-lysine/glutamic acid) multilayer films. In contrast, poly(D-lysine) acts as a barrier to cell communication. For the case of monocytic cells the mechanism of contact with the active protein is elucidated. It is believed that such functionalized coatings could be useful tools for the modification of biomaterial surfaces with applications in, e.g., implants or tissue engineering.

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