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N. Benkirane-Jessel, P. Lavalle, F. Meyer, F. Audouin, B. Frisch, P. Schaaf, J. Ogier, G. Decher and J.-C. Voegel Control of Monocyte Morphology on and Response to Model Surfaces for Implants Equipped with Anti-Inflammatory Agent Advanced Materials 16

Article first published online: 23 SEP 2004 | DOI: 10.1002/adma.200306613

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In order to prevent local chronic inflammation due to biomaterials such as implants, surface coatings that are able to modulate inflammatory response have been developed. It is shown that polyelectrolyte multilayers containing alpha-melanocyte-stimulating hormone (α-MSH) can be advantageously used for this purpose. The presence of α-MSH has been demonstrated to induce cellular responses that can be modulated by varying the film architecture (see Figure).

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