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R. R. Bhat, B. N. Chaney, J. Rowley, A. Liebmann-Vinson and J. Genzer Tailoring Cell Adhesion Using Surface-Grafted Polymer Gradient Assemblies Advanced Materials 17

Article first published online: 11 OCT 2005 | DOI: 10.1002/adma.200500858

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Surface-grafted polymer assemblies with a gradient in molecular weight (MW) and/or grafting density (σ) are used to tune protein adsorption, which consequently governs cell adhesion. Increasing the surface coverage of the polymer by increasing the MW and/or σ results in a decrease in the amount of protein adsorbed, which causes a decrease in the number of cells adhered and a change in cell morphology.

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