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J. Zhang and D. M. Lynn Ultrathin Multilayered Films Assembled from “Charge-Shifting” Cationic Polymers: Extended, Long-Term Release of Plasmid DNA from Surfaces Advanced Materials 19

Article first published online: 7 NOV 2007 | DOI: 10.1002/adma.200701028

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Ultrathin multilayered films can be designed to release plasmid DNA for three months by using side-chain functionalized ‘charge-shifting' cationic polymers. Slow hydrolysis of the side chains of these polymers facilitates film disruption and release of DNA over periods longer than films fabricated using degradable cationic polymers, and suggests approaches to the fabrication of thin films for the localized and long-term release of DNA, proteins, or other agents from surfaces.

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