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Marc D. Roy, Scott K. Stanley, Eric J. Amis and Matthew L. Becker Identification of a Highly Specific Hydroxyapatite-binding Peptide using Phage Display Advanced Materials 20

Article first published online: 15 MAY 2008 | DOI: 10.1002/adma.200702322

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A peptide sequence SVSVGMKPSPRP that selectively recognizes hydroxyapatite (HA) is identified by using a phage display approach. The engineered sequence exhibits chemical and structural specificity for HA over calcium carbonate and HA's amorphous calcium phosphate precursor. In situ binding to HA in a tooth cross section further demonstrates the sequence specificity and utility in nondestructive imaging applications.

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