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Hsiung-Lin Tu, Yu-Shen Lin, Hsia-Yu Lin, Yann Hung, Leu-Wei Lo, Yang-Fang Chen and Chung-Yuan Mou In vitro Studies of Functionalized Mesoporous Silica Nanoparticles for Photodynamic Therapy Advanced Materials 21

Version of Record online: 2 JAN 2009 | DOI: 10.1002/adma.200800548

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A versatile platform for photodynamic therapy (PDT), mesoporous silica nanoparticles functionalized with protoporphyrin IX (PpIX-MSNs), has been developed. In vitro studies on HeLa cells show high uptake efficiency. Phototoxicity results give both irradiation time- and dosage-dependent cell death events. Because of the ease of incorporating other biomedical functional groups, we believe MSNs would be an ideal platform for biomedical applications.

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