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Sonja Bauhuber, Constantin Hozsa, Miriam Breunig and Achim Göpferich Delivery of Nucleic Acids via Disulfide-Based Carrier Systems Advanced Materials 21

Version of Record online: 27 JUL 2009 | DOI: 10.1002/adma.200802453

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Materials containing disulfide bonds are very promising for the delivery of nucleic acids into cells, because they exploit the redox gradient between the extra- and intracellular compartment. This review gives an overview of the biological rationale for the synthesis of redox-sensitive, disulfide-based carrier systems. In particular, the basic synthesis approaches for introducing disulfide bonds into carrier molecules are presented.

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