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Daniel A. Bernards and Tejal A. Desai Nanotemplating of Biodegradable Polymer Membranes for Constant-Rate Drug Delivery Advanced Materials 22

Version of Record online: 7 APR 2010 | DOI: 10.1002/adma.200903439

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A nanoporous biodegradable polymer (polycaprolactone) is fabricated utilizing a zinc oxide nanotemplate (see figure). Chemical characterization verifies removal of the template, and preliminary tests on the cytotoxicity demonstrate basic biocompatibility. Diffusion of a model small molecule and a protein are shown to be first and zero order, respectively, indicating these nanoporous membranes may be useful for controlled release of protein-based therapeutics.

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