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Xuan Jiang, Yiran Zheng, Hunter H. Chen, Kam W. Leong, Tza-Huei Wang and Hai-Quan Mao Dual-Sensitive Micellar Nanoparticles Regulate DNA Unpacking and Enhance Gene-Delivery Efficiency Advanced Materials 22

Article first published online: 3 MAY 2010 | DOI: 10.1002/adma.200903933

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Reversibly crosslinked micellar nanoparticles that are capable of releasing encapsulated DNA in response to a reduction microenvironment and physiological ionic strength are synthesized for gene delivery. The dual-sensitive nanoparticles exhibit significantly enhanced complex and colloidal stability, yield more sustained DNA unpacking in cytosols, and mediate enhanced and more prolonged transgene expression for at least 10 days.

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