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Peter C. DeMuth, Xingfang Su, Raymond E. Samuel, Paula T. Hammond and Darrell J. Irvine Nano-Layered Microneedles for Transcutaneous Delivery of Polymer Nanoparticles and Plasmid DNA Advanced Materials 22

Article first published online: 21 SEP 2010 | DOI: 10.1002/adma.201001525

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Multilayer-coated microneedles achieve transcutaneous delivery of plasmid DNA to the viable epidermis. Cy3-labeled plasmid DNA encoding luciferase (yellow) is deposited on biodegradable microneedle arrays through multilayer self-assembly and then delivered to the skin by microneedle application to achieve colocalization with Langerhans dendritic cells (MHC II-GFP–green).

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