Minglin Ma, Wendy F. Liu, Paulina S. Hill, Kaitlin M. Bratlie, Daniel J. Siegwart, Justin Chin, Miri Park, Joao Guerreiro and Daniel G. Anderson Development of Cationic Polymer Coatings to Regulate Foreign-Body Responses Advanced Materials 23
A library of cationic polymers, poly(beta-amino alcohols) with a great chemical diversity are synthesized using combinatorial polymerization. These polymers, when immobilized on a surface, drastically affect the behavior of monocyte/macrophage cells in vitro and early inflammatory reactions in vivo. Certain polymers are found capable of mitigating the foreign-body responses.
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