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Di Cui, Jing Jing, Thomas Boudou, Isabelle Pignot-Paintrand, Stefaan De Koker, Bruno G. De Geest, Catherine Picart and Rachel Auzély-Velty Hydrophobic Shell Loading of Biopolyelectrolyte Capsules Advanced Materials 23

Article first published online: 17 MAY 2011 | DOI: 10.1002/adma.201100600

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A versatile method to selectively encapsulate water-insoluble molecules in the nanoshell of layer-by-layer capsules made exclusively of polysaccharides is described. This relies on the very high affinity of hydrophobic molecules for an alkylated hyaluronic acid used as a polyanionic partner of a chitosan derivative for the capsule synthesis. The hydrophobic molecules entrapped in the nanoshell can be delivered intracellularly in dendritic cells.

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