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Lingyan Feng, Li Wu, Jiasi Wang, Jinsong Ren, Daisuke Miyoshi, Naoki Sugimoto and Xiaogang Qu Detection of a Prognostic Indicator in Early-Stage Cancer Using Functionalized Graphene-Based Peptide Sensors Advanced Materials 24

Article first published online: 5 DEC 2011 | DOI: 10.1002/adma.201103205

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Using a porphyrin-functionalized graphene-modified electrode, an electrochemical impedance peptide sensor for label-free detection of cyclin A2 has been constructed. This electrochemical sensor can not only detect protein in cancer cells but also differentiate cancer cells from normal ones. Furthermore, the assay provides the potential of using a simple electrochemical technique to estimate the efficiency of anticancer drugs in cancer therapy.

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