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Aaron Chen, Deborah K. Lieu, Lauren Freschauf, Valerie Lew, Himanshu Sharma, Jiaxian Wang, Diep Nguyen, Ioannis Karakikes, Roger J. Hajjar, Ajay Gopinathan, Elliot Botvinick, Charless C. Fowlkes, Ronald A. Li and Michelle Khine Shrink-Film Configurable Multiscale Wrinkles for Functional Alignment of Human Embryonic Stem Cells and their Cardiac Derivatives Advanced Materials 23

Version of Record online: 8 NOV 2011 | DOI: 10.1002/adma.201103463

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A biomimetic substrate for cell-culture is fabricated by plasma treatment of a prestressed thermoplastic shrink film to create tunable multiscaled alignment “wrinkles”. Using this substrate, the functional alignment of human embryonic stem cell derived cardiomyocytes is demonstrated.

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