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Caroline M. Curtin, Gráinne M. Cunniffe, Frank G. Lyons, Kazuhisa Bessho, Glenn R. Dickson, Garry P. Duffy and Fergal J. O'Brien Innovative Collagen Nano-Hydroxyapatite Scaffolds Offer a Highly Efficient Non-Viral Gene Delivery Platform for Stem Cell-Mediated Bone Formation Advanced Materials 24

Version of Record online: 2 JAN 2012 | DOI: 10.1002/adma.201103828

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The ability of nano-hydroxyapatite (nHA) particles developed in-house to act as non-viral delivery vectors is assessed. These nHA particles are combined with collagen to yield bioactive, biodegradable collagen nano-hydroxyapatite (coll-nHA) scaffolds. Their ability to act as gene-activated matrices for BMP2 delivery is demonstrated with successful transfection of mesenchymal stem cells (MSCs) resulting in high calcium production.

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