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Peng Li, Chuncai Zhou, Shahrzad Rayatpisheh, Kai Ye, Yin Fun Poon, Paula T. Hammond, Hongwei Duan and Mary B. Chan-Park Cationic Peptidopolysaccharides Show Excellent Broad-Spectrum Antimicrobial Activities and High Selectivity Advanced Materials 24

Article first published online: 21 MAR 2012 | DOI: 10.1002/adma.201104186

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Facilely synthesized cationic peptidopolysaccharides, which have a bacterial peptidoglycan-mimetic structure, show outstanding broad-spectrum activities against clinically significant bacteria and fungi and low mammalian cytotoxicity. Their structural affinity with microbial cell-wall constituents promotes penetration to reach the cytoplasmic membrane resulting in excellent antimicrobial activity and high selectivity.

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