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Justin G. Railsback, Abhishek Singh, Ryan C. Pearce, Timothy E. McKnight, Ramón Collazo, Zlatko Sitar, Yaroslava G. Yingling and Anatoli V. Melechko Weakly Charged Cationic Nanoparticles Induce DNA Bending and Strand Separation Advanced Materials 24

Version of Record online: 19 JUN 2012 | DOI: 10.1002/adma.201104891

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Weakly charged cationic nanoparticles cause structural changes including local denaturing and compaction to DNA under mild conditions. The charged ligands bind to the phosphate backbone of DNA and the uncharged ligands penetrate the helix and disrupt base pairing. Mobility shifts in electrophoresis, molecular dynamics, and UV-vis spectrophotometry give clues to the details of the interactions.

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