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Luo Gu, Laura E. Ruff, Zhengtao Qin, Maripat Corr, Stephen M. Hedrick and Michael J. Sailor Multivalent Porous Silicon Nanoparticles Enhance the Immune Activation Potency of Agonistic CD40 Antibody Advanced Materials 24

Version of Record online: 12 JUN 2012 | DOI: 10.1002/adma.201200776

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Porous silicon nanoparticles, each containing multiple copies of an agonistic antibody (blue) to the antigen-presenting cell (APC) receptor CD40 (red), greatly enhance activation of APCs. The much larger (30–40 fold) cellular response to the nanoparticle-bound antibody stimulators is attributed to multivalent interactions between the antibody ensemble and the CD40 targets.

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