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Matthew A. Nakatsuka, Robert F. Mattrey, Sadik C. Esener, Jennifer N. Cha and Andrew P. Goodwin Aptamer-Crosslinked Microbubbles: Smart Contrast Agents for Thrombin-Activated Ultrasound Imaging Advanced Materials 24

Article first published online: 3 SEP 2012 | DOI: 10.1002/adma.201201484

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Thrombosis, or malignant blood clotting, is associated with numerous cardiovascular diseases and cancers. A microbubble contrast agent is presented that produces ultrasound harmonic signal only when exposed to elevated thrombin levels. Initially silent microbubbles are activated in the presence of both thrombin-spiked and freshly clotting blood in three minutes with detection limits of 20 nM thrombin and 2 aM microbubbles.

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