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Halil Tekin, Jefferson G. Sanchez, Christian Landeros, Karen Dubbin, Robert Langer and Ali Khademhosseini Controlling Spatial Organization of Multiple Cell Types in Defined 3D Geometries Advanced Materials 24

Article first published online: 3 SEP 2012 | DOI: 10.1002/adma.201201805

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A simple method to control spatial organizations of multiple cell types in predefined geometries by using poly(N-isopropylacrylamide)-based dynamic microwells is described. Dynamic microwells are used to pattern two different cell types in a spatially controlled manner by exploiting their shape changing properties at two different temperatures. Both spatial organization of two different cell types and control of pattern geometry are achieved with circular and square dynamic microwells.

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