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Shao Qiong Liu, Chuan Yang, Yuan Huang, Xin Ding, Yan Li, Wei Min Fan, James L. Hedrick and Yi-Yan Yang Antimicrobial and Antifouling Hydrogels Formed In Situ from Polycarbonate and Poly(ethylene glycol) via Michael Addition Advanced Materials 24

Article first published online: 27 SEP 2012 | DOI: 10.1002/adma.201202225

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A novel class of antimicrobial cationic polycarbonate/PEG hydrogels are designed and synthesized by Michael addition chemistry. These hydrogels demonstrate strong broad-spectrum antimicrobial activities against various clinically isolated multidrug-resistant microbes. Moreover, they exhibit nonfouling properties and prevent the substrate from microbial adhesion. These antimicrobial and antifouling gels are promising materials as catheter coatings and wound dressings to prevent infections.

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