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Siddharth Jhunjhunwala, Giorgio Raimondi, Andrew J. Glowacki, Sherri J. Hall, Dan Maskarinec, Stephen H. Thorne, Angus W. Thomson and Steven R. Little Bioinspired Controlled Release of CCL22 Recruits Regulatory T Cells In Vivo Advanced Materials 24

Version of Record online: 23 JUL 2012 | DOI: 10.1002/adma.201202513

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A rationally designed controlled-release system is developed to recruit suppressive immune cells to specific sites in vivo. Continuous and sustained release of the chemokine CCL22 is achieved by fabricating porous polymeric microspheres. Application of these porous particles in vivo, in mice, leads to local regulatory T cell recruitment as well as a delay in rejection responses against transplanted allogeneic cells.

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