Cheng-Hwa R. Kuo, Jian Xian, James D. Brenton, Kristian Franze and Easan Sivaniah Complex Stiffness Gradient Substrates for Studying Mechanotactic Cell Migration Advanced Materials 24
Polyacrylamide gels are cast upon a stiff support with controlled topography, resulting in a thin gel layer of variable height. The topographical profiles project a stiffness map onto the gel, resulting in controlled linear and non-linear 2D stiffness gradients. Fibroblasts, which migrate towards stiffer substrates, accumulate in areas with a gel thickness below 15 μm.
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