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Ruogang Zhao, Thomas Boudou, Wei-Gang Wang, Christopher S. Chen and Daniel H. Reich Decoupling Cell and Matrix Mechanics in Engineered Microtissues Using Magnetically Actuated Microcantilevers Advanced Materials 25

Version of Record online: 28 JAN 2013 | DOI: 10.1002/adma.201203585

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A novel bio-magnetomechanical microtissue system is described for magnetic actuation of arrays of 3D microtissues using microcantilevers. This system enables both in situ measurements of fundamental mechanical properties of engineered tissue, such as contractility and stiffness, as well as dynamic stimulation of the microtissues. Using this system, cell and extracellular matrix contributions to the tissue mechanical properties are decoupled for the first time under both static and dynamic loading conditions.

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