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S. Sangiambut, K. Channon, N. M. Thomson, S. Sato, T. Tsuge, Y. Doi and E. Sivaniah A Robust Route to Enzymatically Functional, Hierarchically Self-Assembled Peptide Frameworks Advanced Materials 25

Article first published online: 22 JAN 2013 | DOI: 10.1002/adma.201204127

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The addition of enzyme biofunctionality to self-assembling peptide nanofibers is challenging since such additions can inhibit functionality or self-assembly. We introduce a method for peptide nanofiber enzyme functionalization, demonstrated by the attachment of a polymerization synthase to peptide nanofibers. The enzyme generates a biocompatible, biodegradable biopolyester coat on the fibers with applicablity in medical engineering. This approach provides a template for generation of functional bionanomaterials.

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