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Qiuning Lin, Chunyan Bao, Yunlong Yang, Qiannan Liang, Dasheng Zhang, Shuiyu Cheng and Linyong Zhu Highly Discriminating Photorelease of Anticancer Drugs Based on Hypoxia Activatable Phototrigger Conjugated Chitosan Nanoparticles Advanced Materials 25

Article first published online: 7 FEB 2013 | DOI: 10.1002/adma.201204455

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An ultimately selective photorelease system of chitosan-nanoparticles is constructed. Only under unique aspects of tumor-hypoxia physiological conditions, the preliminary locked phototrigger is unlocked by biological reduction to enable the release of the caged drug either by visible light or two-photon near-IR (NIR) excitation. This approach provides a highly discriminating photorelease of anticancer drug to hypoxic tumor cells, but not to healthy normal cells.

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