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Chunlei Zhu, Qiong Yang, Fengting Lv, Libing Liu and Shu Wang Conjugated Polymer-Coated Bacteria for Multimodal Intracellular and Extracellular Anticancer Activity Advanced Materials 25

Article first published online: 20 DEC 2012 | DOI: 10.1002/adma.201204550

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Multifunctional cationic conjugated polyelectrolyte (CP)-coated bacteria are fabricated for drug loading, delivery and release with multimodal anticancer activity. Facilitated by the collaborative release effect caused by CP and an antibiotic polymyxin B, the loaded toxins leak out from the vectors in considerable amounts and lead to tumor cell death. In addition, the CP coated bacterial vectors can sentisize ROS, which favors light-mediated tumor cell killing.

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