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Shouju Wang, Peng Huang, Liming Nie, Ruijun Xing, Dingbin Liu, Zhe Wang, Jing Lin, Shouhui Chen, Gang Niu, Guangming Lu and Xiaoyuan Chen Single Continuous Wave Laser Induced Photodynamic/Plasmonic Photothermal Therapy Using Photosensitizer-Functionalized Gold Nanostars Advanced Materials 25

Version of Record online: 13 FEB 2013 | DOI: 10.1002/adma.201204623

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Chlorin e6 conjugated gold nanostars (GNS-PEG-Ce6) are used to perform simultaneous photodynamic/plasmonic photothermal therapy (PDT/PPTT) upon single laser irradiation. The early-phase PDT effect is coordinated with the late-phase PPTT effect to obtain synergistic anticancer efficiency. The prepared GNS-PEG-Ce6 shows excellent water dispersibility, good biocompatibility, enhanced cellular uptake and remarkable anticancer efficiency upon irradiation in vivo.

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