Gregory N. Grover, Rebecca L. Braden and Karen L. Christman Oxime Cross-Linked Injectable Hydrogels for Catheter Delivery Advanced Materials 25
Catheter delivery of therapeutic materials is important for developing minimally invasive treatment approaches. However, the majority of injectable materials gel rapidly upon mixing and/or heating to body temperature. The application of an oxime cross-linked hydrogel system is demonstrated. The system has a broad range of tunable gelation rates, is capable of injection through a catheter, and exhibits rapid gelation upon injection into tissue.
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