Valentina Dallacasagrande, Mareike Zink, Steven Huth, Alexander Jakob, Marcus Müller, Andreas Reichenbach, Josef A. Käs and S. G. Mayr Tissue Engineering: Tailoring Substrates for Long-Term Organotypic Culture of Adult Neuronal Tissue (Adv. Mater. 18/2012) Advanced Materials 24
Organotypic culture of adult neuronal tissue over several weeks is an unresolved challenge due to rapid distortion and cell death. M. Zink, S. G. Mayr, and co-workers demonstrate for the first time on page 2399 that superhydrophilic nanostructured substrates with tunable surface morphologies offer ideal conditions for culturing adult retinal explants (upper right) and adult brain slices (lower left). Even after two weeks, the neuronal tissue structures are maintained without signs of degeneration, which paves the way for in-vitro retina and brain tissue regeneration.
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