Siowling Soh, Kristiana Kandere-Grzybowska, Goher Mahmud, Sabil Huda, Alexander Z. Patashinski and Bartosz A. Grzybowski Micropatterning: Tomography and Static-Mechanical Properties of Adherent Cells (Adv. Mater. 42/2012) Advanced Materials 24
A tomography approach is used to reconstruct 3D cell shapes and the shapes/positions of the nuclei within these cells simultaneously. Bartosz A. Grzybowski, Kristiana Kandere-Grzybowska and co-workers show on page 5719 that cells subjected to well-defined microconfinements of various diameters allow for relating the steady-state shapes of cells to their staticmechanical properties. The observed shapes show striking regularities between different cell types and all fit to a model that takes into account the cell membrane, cortical actin, and the nucleus.
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