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Deepak H. Veeregowda, Anke Kolbe, Henny C. van der Mei, Henk J. Busscher, Andreas Herrmann and Prashant K. Sharma Recombinant Supercharged Polypeptides Restore and Improve Biolubrication Advanced Materials 25

Article first published online: 22 MAY 2013 | DOI: 10.1002/adma.201300188

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Recombinant supercharged polypeptides (SUPs) with low cytotoxicity are developed and applied to rejuvenate the lubrication of naturally occurring salivary conditioning films (SCFs). SUPs with 72 positive charges adsorbed and rigidified the SCFs and recruited mucins to form a hydrated layer. These SCFs with SUPs have higher mechanical strength and sustain lubricating effect for longer duration compared with only SCFs.

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