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Akhilesh K. Gaharwar, Silvia M. Mihaila, Archana Swami, Alpesh Patel, Shilpa Sant, Rui L. Reis, Alexandra P. Marques, Manuela E. Gomes and Ali Khademhosseini Bioactive Silicate Nanoplatelets for Osteogenic Differentiation of Human Mesenchymal Stem Cells Advanced Materials 25

Version of Record online: 13 MAY 2013 | DOI: 10.1002/adma.201300584

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Novel silicate nanoplatelets that induce osteogenic differentiation of human mesenchymal stem cells (hMSCs) in the absence of any osteoinductive factor are reported. The presence of the silicate triggers a set of events that follows the temporal pattern of osteogenic differentiation. These findings underscore the potential applications of these silicate nanoplatelets in designing bioactive scaffolds for musculoskeletal tissue engineering.

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