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Federico Picollo, Sara Gosso, Ettore Vittone, Alberto Pasquarelli, Emilio Carbone, Paolo Olivero and Valentina Carabelli A New Diamond Biosensor with Integrated Graphitic Microchannels for Detecting Quantal Exocytic Events from Chromaffin Cells Advanced Materials 25

Article first published online: 12 JUL 2013 | DOI: 10.1002/adma.201300710

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An MeV ion-microbeam lithographic technique can be successfully employed for the fabrication of an all-carbon miniaturized cellular biosensor based on graphitic microchannels embedded in a single-crystal diamond matrix. The device is functionally characterized for the in vitro recording of quantal exocytic events from single chromaffin cells, with high sensitivity and signal-to-noise ratio, opening promising perspectives for the realization of monolithic all-carbon cellular biosensors.

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