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Miao-Ping Chien, Matthew P. Thompson, Christopher V. Barback, Ti-Hsuan Ku, David J. Hall and Nathan C. Gianneschi Enzyme-Directed Assembly of a Nanoparticle Probe in Tumor Tissue Advanced Materials 25

Version of Record online: 28 MAY 2013 | DOI: 10.1002/adma.201300823

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Enzyme-directed assembly in vivo: A targeting strategy is demonstrated, which leads to an active accumulation of nanoparticles by virtue of an assembly event specific to endogenous, enzymatic biochemical signals associated with tumor tissue. The viability of this approach is examined through a proof-of-concept study showing enzyme-directed particle targeting and accumulation in human xenograft tumors in mice following intravenous injection, and the retention of particles is demonstrated within tumors for extended periods of time.

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