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Jinqiang Wang, Xuanrong Sun, Weiwei Mao, Weilin Sun, Jianbin Tang, Meihua Sui, Youqing Shen and Zhongwei Gu Tumor Redox Heterogeneity-Responsive Prodrug Nanocapsules for Cancer Chemotherapy Advanced Materials 25

Version of Record online: 6 JUN 2013 | DOI: 10.1002/adma.201300929

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A prodrug forms nanocapsules responsive to tumor GSH/ROS heterogeneity releasing the parent drug SN38 via thiolysis in the presence of GSH (glutathione) or via enhanced hydrolysis due to ROS (reactive oxygen species)-oxidation of the linker, giving rise to high in vitro cytotoxicity and in vivo anticancer therapeutic activity. The nanocapsules are a suitable size for tumor targeting by means of the EPR effect and have a fixed SN38 loading content of 35 wt%, ideal for translational nanomedicine.

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