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Martin E. Kolewe, Hyoungshin Park, Caprice Gray, Xiaofeng Ye, Robert Langer and Lisa E. Freed 3D Structural Patterns in Scalable, Elastomeric Scaffolds Guide Engineered Tissue Architecture Advanced Materials 25

Version of Record online: 14 JUN 2013 | DOI: 10.1002/adma.201301016

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Microfabricated elastomeric scaffolds with 3D structural patterns are created by semiautomated layer-by-layer assembly of planar polymer sheets with through-pores. The mesoscale interconnected pore architectures governed by the relative alignment of layers are shown to direct cell and muscle-like fiber orientation in both skeletal and cardiac muscle, enabling scale up of tissue constructs towards clinically relevant dimensions.

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