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Bicheng He, Yuan Chu, Meizhen Yin, Klaus Müllen, Chunju An and Jie Shen Fluorescent Nanoparticle Delivered dsRNA Toward Genetic Control of Insect Pests Advanced Materials 25

Version of Record online: 24 JUN 2013 | DOI: 10.1002/adma.201301201

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A fluorescent cationic core-shell nanoparticle efficiently enters into cells with high transfection efficacy. A FNP/CHT10-dsRNA complex is orally fed to insect pests and knocks down a midgut-specific chitinase gene of the Asian corn borer, which leads to death. This is the first report on the genetic control of insect pests through a non-viral gene delivery system to knock down key developmental gene expression.

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