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Fuping Gao, Linlin Li, Changhui Fu, Liya Nie, Dong Chen and Fangqiong Tang LHRH-PE40 Fusion Protein Tethered Silica Nanorattles for Imaging-Guided Tumor-Specific Drug Delivery and Bimodal Therapy Advanced Materials 25

Version of Record online: 22 JUL 2013 | DOI: 10.1002/adma.201301217

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Docyanine green (ICG) and LHRH-PE40 fusion protein are tethered onto drug carriers of silica nanorattles for imaging-guided tumor-specific drug delivery and bimodal therapy. The synergistic therapeutic effect of toxin PE40 and the chemotherapeutic drug docetaxel (Dtxl), specifically directed by LHRH to cancer, improves cancer treatment. Simultaneously, ICG enables real-time monitoring of the silica nanocomposites and therapeutic response.

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