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Yang Zhou, Zhigang Wang, Yu Chen, Hongxia Shen, Zhenchun Luo, Ao Li, Qi Wang, Haitao Ran, Pan Li, Weixiang Song, Zhu Yang, Hangrong Chen, Zhibiao Wang, Guangmin Lu and Yuanyi Zheng Microbubbles from Gas-Generating Perfluorohexane Nanoemulsions for Targeted Temperature-Sensitive Ultrasonography and Synergistic HIFU Ablation of Tumors Advanced Materials 25

Article first published online: 21 JUN 2013 | DOI: 10.1002/adma.201301655

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A special “small to big” temperature-responsive phase-transformation strategy based on the “acoustic droplet vaporization (ADV)” mechanism is developed for efficient targeted ultrasonography and synergistic high intensity focused ultrasound (HIFU) cancer surgery by engineering targeted nanoemulsions, which is systematically evaluated and successfully demonstrated in vitro, ex vivo, and in vivo.

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