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Ping'an Ma, Haihua Xiao, Xiaoxue Li, Chunxia Li, Yunlu Dai, Ziyong Cheng, Xiabin Jing and Jun Lin Rational Design of Multifunctional Upconversion Nanocrystals/Polymer Nanocomposites for Cisplatin (IV) Delivery and Biomedical Imaging Advanced Materials 25

Version of Record online: 15 JUL 2013 | DOI: 10.1002/adma.201301713

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By combining upconversion nanoparticles with the cisplatin (IV) prodrug we have demonstrated that a stable and multifunctional drug delivery system can be designed that will both reduce the drawbacks of cisplatin and give insight in to its in vitro/in vivo imaging. The up/down-conversion fluorescence are detectable and show obvious co-localization, demonstrating that the nanoparticles are rather stable inside cells and retain the UCNPs and block copolymer.

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