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Chih-Te Chien, Jia-Ying Yan, Wan-Ching Chiu, Te-Haw Wu, Chia-Yeh Liu and Shu-Yi Lin Caged Pt Nanoclusters Exhibiting Corrodibility to Exert Tumor-Inside Activation for Anticancer Chemotherapeutics Advanced Materials 25

Article first published online: 2 AUG 2013 | DOI: 10.1002/adma.201302363

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We report on caged Pt nanoclusters that are able to exert tumor-inside activation for anticancer chemotherapeutics and to minimize systemic toxicity. By shrinking the Pt size to 1 nm, it possesses corrodibility for dissolution in weakly acidic organelles to release toxic Pt ions. The therapeutic effect in exerting tumor-inside activation is confirmed in vivo by post-modifying a pH-cleavable PEG corona and mixing it with a tumor-homing peptide for tumour suppression.

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