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Yuefei Shen, Shiyi Zhang, Fuwu Zhang, Alexander Loftis, Adriana Pavía-Sanders, Jiong Zou, Jingwei Fan, John-Stephen A. Taylor and Karen L. Wooley Polyphosphoester-Based Cationic Nanoparticles Serendipitously Release Integral Biologically-Active Components to Serve as Novel Degradable Inducible Nitric Oxide Synthase Inhibitors Advanced Materials 25

Version of Record online: 3 SEP 2013 | DOI: 10.1002/adma.201302842

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A degradable polyphosphoester (PPE)-based cationic nanoparticle (cSCK), which is integrated constructed as a novel degradable drug device, demonstrates surprisingly efficient inhibition of inducible nitric oxide synthase (iNOS) transcription, and eventually inhibits nitric oxide (NO) over-production, without loading of any specific therapeutic drugs. This system may serve as a promising anti-inflammatory agent toward the treatment of acute lung injury.

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