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Qianjun He and Jianlin Shi MSN Anti-Cancer Nanomedicines: Chemotherapy Enhancement, Overcoming of Drug Resistance, and Metastasis Inhibition Advanced Materials 26

Article first published online: 20 OCT 2013 | DOI: 10.1002/adma.201303123

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Anti-cancer nanomedicine: mesoporous silica nanoparticle (MSN) nanomedicines functionalized with targeting, burst responsive, and payload units, as well as a stealth coating, can enhance the chemotherapeutic efficacy and lower toxic side effects by tumor/cell membrane/nuclear-targeted drug delivery and pH/redox/protease-responsive drug release. Moreover, MSN nanomedicines overcome multi-drug resistance by the multi-drug synergy strategy, the effluxcircumventing strategy, and the multimodal combination therapy strategy, and inhibit tumor metastasis.

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