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Li Zhou, Zhaowei Chen, Kai Dong, Meili Yin, Jinsong Ren and Xiaogang Qu DNA-mediated Construction of Hollow Upconversion Nanoparticles for Protein Harvesting and Near-Infrared Light Triggered Release Advanced Materials 26

Article first published online: 17 DEC 2013 | DOI: 10.1002/adma.201304437

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A simple DNA-mediated solvothermal method has been developed for the construction of well-defined hollow UNPs that can be used for a new paradigm to realize NIR light-controlled non-invasive protein release. In vitro studies show that the UNPs are capable of the transportation of enzyme into living cells. Intracellular NIR triggers the release of enzymes with high spatial and temporal precision and the released enzyme also retains its biological activity.

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