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Y.H. Huang, H.P. Ho, S.K. Kong and A.V. Kabashin Phase-sensitive surface plasmon resonance biosensors: methodology, instrumentation and applications Annalen der Physik 524

Version of Record online: 14 NOV 2012 | DOI: 10.1002/andp.201200203

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Surface Plasmon Resonance (SPR) has become a central tool for label-free characterization of biomolecular interactions. Conventional SPR sensors have been extensively explored and applied, but it still lacks sensitivity for the detection of relatively small and low copy number compounds. Phase-sensitive SPR has recently emerged as an upgrade of this technology, which enables to solve the sensitivity problem. This paper provides a tutorial on phase detection in SPR sensing.

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