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Prof. Dr. Helmut Sies Biochemistry of Oxidative Stress Angewandte Chemie International Edition in English 25

Version of Record online: 22 DEC 2003 | DOI: 10.1002/anie.198610581

Even the oxygen we breath has its negative side: a normal consequence of aerobic life is the structural damage done to a large number of compounds—DNA, proteins, carbohydrates, lipids—by reactive oxygen species such as Omath image, O⊖⊙, HOmath image, HO, H2O2, Omath image, and 1O2. A large number of biological processes, including inflammation, carcinogenesis, ageing, and damage due to radiation, are caused or influenced by these species. To defend themselves, biological organisms have evolved both enzymatic and nonenzymatic antioxidant systems. Knowledge in this area affords new insights for biochemical pharmacology and toxicology as well as for radiation biochemistry.

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